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Test Code 11INT Factor XI Inhibitor Profile, Technical Interpretation


Specimen Required


Only orderable as part of a profile. For more information see 11INE / Factor XI Inhibitor Evaluation, Plasma


Secondary ID

607441

Useful For

Technical interpretation of inhibitor to coagulation factor XI testing

 

This test is not useful for the detection of a lupus-like circulating anticoagulant inhibitor, a nonspecific circulating anticoagulant, or other inhibitors that are not specific for coagulation factors.

Method Name

Only orderable as part of a profile. For more information see 11INE / Factor XI Inhibitor Evaluation, Plasma

 

Technical Interpretation

Reporting Name

FXI Inhib Profile Tech Interp

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

Factor XI inhibitors typically arise in patients with congenital XI deficiency (hemophilia C) or after infusion of fresh frozen plasma or factor XI concentrates. Acquired factor XI inhibitors rarely occur spontaneously.

Reference Values

Only orderable as part of a profile. For more information see 11INE / Factor XI Inhibitor Evaluation, Plasma

 

An interpretive report will be provided.

Interpretation

When testing is complete, if factor activity results fall within clinically normal ranges, an interpretive comment will be provided noting that inhibitor testing was not indicated and, therefore, not performed. If factor activity indicates the performance of inhibitor screen testing, an interpretive comment will be provided noting the presence or absence of a factor XI inhibitor.

Cautions

Occasionally, a potent lupus-like anticoagulant may cause false-positive testing for a specific factor inhibitor (eg, factor VIII or IX).

Clinical Reference

1. Hoffman R, Benz Jr EJ, Silberstein LE, et al, eds: Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018

2. Kasper CK. Treatment of factor VIII inhibitors. Prog Hemost Thromb 1989;9:57-86

3. Kottke-Marchant K, ed. Laboratory Hematology Practice Wiley Blackwell Publishing; 2012

Method Description

If the factor XI activity level is normal or elevated, a computer-generated interpretive comment indicating inhibitor testing was not indicated and was not performed will be provided.

Day(s) Performed

Monday through Friday

Report Available

3 to 5 days

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

Not Applicable

CPT Code Information

85390

LOINC Code Information

Test ID Test Order Name Order LOINC Value
11INT FXI Inhib Profile Tech Interp 69049-5

 

Result ID Test Result Name Result LOINC Value
11INT FXI Inhib Profile Tech Interp 69049-5