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HelpTest Code 2INHT Factor II Inhibitor Profile, Technical Interpretation
Specimen Required
Only orderable as part of a profile. For more information see 2INHE / Factor II Inhibitor Evaluation, Plasma.
Secondary ID
607438Useful For
Technical interpretation of inhibitor to factor II testing
This test is not useful for the detection of a lupus-like circulating anticoagulant inhibitor, a nonspecific circulating anticoagulant, or other inhibitors that are not specific for coagulation factors.
Method Name
Only orderable as part of a profile. For more information see 2INHE / Factor II Inhibitor Evaluation, Plasma.
Technical Interpretation
Reporting Name
FII Inhib Profile Tech InterpSpecimen Type
Plasma Na CitSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
Coagulation factor inhibitors arise in patients who are congenitally deficient in a specific factor in response to factor replacement therapy or can either occur spontaneously without known cause or in response to a variety of medical conditions, including the postpartum state, immunologic disorders, certain antibiotic therapies, some malignancies, and in the older population.
Inhibitors of factor VIII coagulant activity are the most commonly occurring of the specific factor inhibitors.
Reference Values
Only orderable as part of a profile. For more information see 2INHE / Factor II Inhibitor Evaluation, Plasma.
An interpretive report will be provided.
Interpretation
When testing is complete, if factor activity results fall within clinically normal ranges, an interpretive comment will be provided noting that inhibitor testing was not indicated and, therefore, not performed. If factor activity indicates the performance of inhibitor screen testing, an interpretive comment will be provided noting the presence or absence of a factor II inhibitor.
Cautions
Occasionally, a potent lupus-like anticoagulant may cause false-positive testing for a specific factor inhibitor (eg, factor VIII or IX).
Clinical Reference
1. Hoffman R, Benz Jr EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018
2. Kasper CK: Treatment of factor VIII inhibitors. Prog Hemost Thromb. 1989;9:57-86
3. Kottke-Marchant K, ed. Laboratory Hematology Practice. Wiley Blackwell Publishing; 2012
Method Description
If the factor II activity level is normal or elevated, a computer-generated interpretive comment will be provided indicating inhibitor testing was not indicated and was not performed.
Day(s) Performed
Monday through FridayReport Available
3 to 5 daysSpecimen Retention Time
7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableCPT Code Information
85390
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| 2INHT | FII Inhib Profile Tech Interp | 69049-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 2INHT | FII Inhib Profile Tech Interp | 69049-5 |