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Test Code 5INHT Factor V Inhibitor Profile, Technical Interpretation


Specimen Required


Only orderable as part of a profile. For more information see 5INHE / Factor V Inhibitor Evaluation, Plasma.


Secondary ID

607437

Useful For

Technical interpretation of inhibitor to factor V testing

Method Name

Only orderable as part of a profile. For more information see 5INHE / Factor V Inhibitor Evaluation, Plasma.

 

Technical Interpretation

Reporting Name

FV Inhib Profile Tech Interp

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

Significant bleeding can result from the presence of a coagulation factor inhibitor and could be life threatening. Whether the inhibitor is present due to hemophilia or is of an acquired nature, it greatly complicates the treatment process of a decreased factor level. The titer of the inhibitor may determine the mode of treatment. Bethesda units are a standardization to give a uniform definition of an inhibitor.

Reference Values

Only orderable as part of a profile. For more information see 5INHE / Factor V Inhibitor Evaluation, Plasma.

 

An interpretive report will be provided.

Interpretation

When testing is complete, if factor activity results fall within clinically normal ranges, an interpretive comment will be provided noting that inhibitor testing was not indicated and, therefore, not performed. If factor activity indicates the performance of inhibitor screen testing, an interpretive comment will be provided noting the presence or absence of a factor V inhibitor.

Cautions

Occasionally, a potent lupus-like anticoagulant may cause false-positive testing for a specific factor inhibitor (eg, factor VIII or IX).

Clinical Reference

1. Hoffman R, Benz Jr EJ, Silberstein LE, et al, eds: Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018

2. Kasper CK: Treatment of factor VIII inhibitors. Prog Hemost Thromb. 1989;9:57-86

3. Kottke-Marchant K, ed. Laboratory Hematology Practice. Wiley Blackwell Publishing; 2012

Method Description

If the factor V activity level is normal or elevated, a computer-generated interpretive comment indicating inhibitor testing was not indicated and was not performed will be provided.

Day(s) Performed

Monday through Friday

Report Available

3 to 5 days

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

Not Applicable

CPT Code Information

85390

LOINC Code Information

Test ID Test Order Name Order LOINC Value
5INHT FV Inhib Profile Tech Interp 69049-5

 

Result ID Test Result Name Result LOINC Value
5INHT FV Inhib Profile Tech Interp 69049-5