Home
HelpTest Code BHISI Bone Histomorphometry, Consultant Interpretation, Slides Only
Necessary Information
Bone Histomorphometry: Patient Information (T352) must be completed and sent with the specimen. The laboratory requires this information in order to perform testing.
Specimen Required
Specimen Type: Bone
Source: Anterior iliac crest
Slides: 2
Submission Container/Tube: Plastic slide holder
Specimen Volume: A minimum of 1 Goldner Trichrome-stained slide and 1 hematoxylin and eosin-stained slide are required. One tetracycline slide should be submitted as applicable.
Collection Information: For complete instructions see Bone Histomorphometry Specimen Preparation (T579).
Forms
Bone Histomorphometry: Patient Information (T352) is required
Secondary ID
70314Useful For
Identifying undetermined metabolic bone disease in submitted slide specimens
Diagnosing renal osteodystrophy
Diagnosing osteomalacia
Diagnosing osteoporosis
Diagnosing Paget disease
Assessing the effects of therapy
Identifying disorders of the hematopoietic system
Diagnosing aluminum toxicity
Identifying the presence of iron in the bone
Special Instructions
Method Name
Medical Interpretation
Reporting Name
Bone HistoMorph Interp OnlySpecimen Type
VariesSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Ambient | ||
Reject Due To
| Bone Decalcified bone |
Reject |
Clinical Information
Bone histomorphometry is a very sophisticated procedure utilizing full thickness bone biopsy.
Techniques such as 2-time interval labeling with tetracycline permit the direct measurement of the rate of bone formation. The information derived is useful in the diagnosis of metabolic bone diseases including renal osteodystrophy, osteomalacia, and osteoporosis. Other obtainable information relates to disorders such as aluminum toxicity and iron abnormalities.
Reference Values
An interpretive report will be provided.
Interpretation
Clinical endocrinologists trained in histomorphometric techniques review and interpret the histological appearance.
A pathologist interprets the bone marrow from a hematoxylin and eosin-stained slide.
No histomorphometric values are given.
Cautions
Mineralization or bone formation rates can be done only when tetracycline has been administered on a specific schedule prior to biopsy.
Biopsy site of preference is iliac crest.
Clinical Reference
1. Recker RR: Bone Histomorphometry: Techniques and Interpretation. CRC Press; 1983
2. Dempster DW, Compston JE, Drezner MK, et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 2013;28(1):2-17. doi:10.1002/jbmr.1805
3. Chavassieux P, Chapurlat R. Interest of bone histomorphometry in bone pathophysiology investigation: Foundation, present, and future. Front Endocrinol (Lausanne). 2022;13:907914. Published 2022 Jul 28. doi:10.3389/fendo.2022.907914
Method Description
The histologic appearance of all sections is reviewed and interpreted by a clinician-histomorphometrist. A hematoxylin and eosin-stained section is reviewed for abnormalities by a pathologist. Telephone consultations with responsible physicians are carried out whenever possible.(Hodgson SF, Johnson KA, Muhs JM, et al. Outpatient percutaneous biopsy of the iliac crest: methods, morbidity, and patient acceptance. Mayo Clin Proc. 1986;61:28-33)
Day(s) Performed
Monday through Friday
Report Available
21 to 26 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableCPT Code Information
88321
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BHISI | Bone HistoMorph Interp Only | 60570-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 71168 | Interpretation | 59465-5 |
| 71169 | Bone Marrow Interpretation | 51628-6 |
| 71170 | Participated in the Interpretation | No LOINC Needed |
| 71171 | Report electronically signed by | 19139-5 |
| 71172 | Material Received | 22633-2 |
| 71787 | Case Number | 80398-1 |
| 601909 | Disclaimer | 62364-5 |
Specimen Minimum Volume
See Specimen Required