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Test Code CSU Chyluria Screen, Random, Urine

Reporting Name

Chyluria Screen, Random, U

Useful For

Aiding in the diagnosis of chyluria (galacturia)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Necessary Information


Indicate patient's age and sex.

Specimen Required


Patient Preparation: Before specimen collection, the patient should not ingest foods or beverages rich in vitamin C or take vitamin C supplements.

Supplies: Urine Container, 60 mL (T313)

Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 15 mL

Collection Instructions: Collect a first-morning, random urine collection.


Specimen Minimum Volume

15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen (preferred) 10 days
  Refrigerated  10 days
  Ambient  4 hours

Reference Values

No lipoproteins present

Day(s) Performed

Monday through Friday

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82664-Electrophoretic technique, not elsewhere specified (Chylomicrons and lipoproteins)

84311-Spectrophotometry, analyte not specified (Cholesterol)

84478-Triglycerides

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CSU Chyluria Screen, Random, U 95808-2

 

Result ID Test Result Name Result LOINC Value
CHOLU Cholesterol, Random, U 14444-4
TRIGU Triglycerides, Random, U 14450-1
CMTCS Interpretive Comment 95807-4

Clinical Information

Chyluria is a medical condition in which chyle is present in the urine. Chyle is a milky substance composed of lymphatic fluid and chylomicrons formed in the small intestine during the digestion of fatty foods. Chyluria is most prevalent in tropical areas where it is caused by parasitic (Wuchereria bancrofti) infections spread by mosquitoes. Parasitic chyluria is so rare as to be nonexistent in the continental United States. Nonparasitic chyluria causes include traumatic lesions, tumors, lymphangioma, pregnancy, and granulomatous infections.

Interpretation

This assay provides information regarding the fat content in urine fluid. Urinary cholesterol and triglyceride values are normally less than 10 mg/dL. High triglyceride levels in urine may indicate chyluria.

Cautions

Ascorbic acid (vitamin C) interferes with the cholesterol determination and, to a lesser degree, the triglyceride concentration. Ascorbic acid falsely decreases the cholesterol and triglyceride results.

 

Result can be falsely decreased in patients with elevated levels of N-acetyl-p-benzoquinone imine (NAPQI)-a metabolite of acetaminophen, N-acetylcysteine, and metamizole.

Clinical Reference

1. Diamond E, Schapira HE. Chyluria-a review of the literature. Urology. 1985;26(5):427-431

2. Mendu DR, Sternlicht H, Ramanathan LV, et al. Two cases of spontaneous remission of non-parasitic chyluria. Clin Biochem. 2017;50(15):886-888. doi:10.1016/j.clinbiochem.2017.05.002

Method Description

This test involves 2 steps, centrifugation and lipoprotein electrophoresis, to detect the visual presence of chylomicrons. The specimen also is analyzed for cholesterol and triglycerides using an enzymatic colorimetric method. The results of the cholesterol, triglycerides, and lipoprotein electrophoresis are used together to determine whether the sample is chyluria.(Unpublished Mayo information)

Report Available

2 to 5 days

Specimen Retention Time

6 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

Enzymatic Colorimetric/Electrophoresis/Spectrophotometry (SP)

Secondary ID

606921