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Test Code FBUMT Bupropion and Metabolite, Serum


Specimen Required


***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***

Specimen Type: Serum

Collection Container/Tube: Red-top

Submission Container/Tube: Plastic vial

Specimen volume: 1 mL

Collection Instructions:

1. Draw blood in a plain red-top tube(s), serum gel tube is not acceptable.

2. Centrifuge and send 1 mL of serum frozen in a plastic vial.


Secondary ID

75387

Method Name

High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Bupropion and Metabolite, S

Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Frozen 30 days

Reject Due To

Gross Hemolysis Reject
Gross Lipemia OK
Gross Icterus OK
Other Polymer gel separation tube (SST or PST)

Reference Values

Reporting Limit determined each analysis.

Units: ng/mL

Interpretation

Bupropion:

Maximum antidepressant response was observed at trough plasma concentrations of 50 – 100 ng/mL bupropion with virtually no response below 25 ng/mL.

 

Reported average bupropion peak plasma concentrations:

Adults: Single 100 mg IR – 120 ± 10 ng/mL (Males):

150 ± 10 ng/mL (Females)

Adults: Single 200 mg IR -220 ± 20 ng/mL (Males):

270 ± 20 ng/mL (Females)

Adults: Single 150 mg SR - 140 ± 20 ng/mL

Juveniles: 100 mg/day SR for 2 weeks – 25 ± 8 ng/mL

Juveniles: 200 mg/day SR for 2 weeks – 53 ± 22 ng/mL

 

Specimens must be kept frozen. If specimens are not kept frozen, this may cause lower or negative values.

 

Hydroxybupropion:

8 adults (Age 22 – 42) taking thrice daily 100 mg normal release bupropion for 2 weeks had an average peak plasma concentration of 1000 ± 70 ng/mL hydroxybupropion.

Juvenile patients taking once daily, extended release bupropion for two weeks had the following peak plasma concentrations:

100 mg/day (n = 11), 450 ± 210 ng/mL hydroxybupropion

200 mg/day (n = 8), 710 ± 350 ng/mL hydroxybupropion

Day(s) Performed

Monday through Sunday

Report Available

6 to 10 days

Performing Laboratory

NMS Labs

CPT Code Information

80338

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FBUMT Bupropion and Metabolite, S Not Provided

 

Result ID Test Result Name Result LOINC Value
Z3522 Bupropion 6706-6
Z3523 Hydroxybupropion 9418-5

Test Classification

This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.