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HelpTest Code FBUMT Bupropion and Metabolite, Serum
Specimen Required
***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL Serum
Collections Instructions:
1. Centrifuge and aliquot 1 mL of serum into a plastic vial.
2. Send refrigerated.
Secondary ID
75387Method Name
High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Bupropion and Metabolite, SSpecimen Type
Serum RedSpecimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Frozen | 30 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
| Polymer gel separation tube (SST or PST) | Reject |
Reference Values
Reporting limit determined each analysis.
None Detected
Interpretation
Bupropion:
Maximum antidepressant response was observed at trough plasma concentrations of 50-100 ng/mL bupropion with virtually no response below 25 ng/mL.
Reported average bupropion peak plasma concentrations:
Adults:
Males:
Single 100 mg IR: 120 ± 10 ng/mL
Single 200 mg IR:220 ±20 ng/mL
Single 150 mg SR - 140 ±20 ng/mL
Females:
Single 100 mg IR: 150 ±10 ng/mL
Single 200 mg IR: 270 ±20 ng/mL
Single 150 mg SR: 140 ±20 ng/mL
Juveniles:
100 mg/day SR for 2 weeks: 25 ±8 ng/mL
200 mg/day SR for 2 weeks: 53 ±22 ng/mL
Hydroxybupropion:
8 adults (Age 22–42) taking thrice daily 100 mg normal release bupropion for 2 weeks had an average peak plasma concentration of 1000 ±70 ng/mL hydroxybupropion.
Juvenile patients taking once daily, extended-release bupropion for two weeks had the following peak plasma concentrations:
100 mg/day (n = 11): 450 ±210 ng/mL hydroxybupropion
200 mg/day (n = 8): 710 ±350 ng/mL hydroxybupropion
Day(s) Performed
Monday through Sunday
Report Available
6 to 10 daysPerforming Laboratory
NMS LabsCPT Code Information
80338
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FBUMT | Bupropion and Metabolite, S | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z3522 | Bupropion | 6706-6 |
| Z3523 | Hydroxybupropion | 9418-5 |
Test Classification
This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.Clinical Information
Refer to www.nmslabs.com/test-catalog.
Cautions
Specimens must be kept frozen. If specimens are not kept frozen, this may cause lower or negative values.