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HelpTest Code FBUMT Bupropion and Metabolite, Serum
Specimen Required
***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL Serum
Collections Instructions:
1. Centrifuge and aliquot 1 mL of serum into a plastic vial.
2. Send refrigerated.
Secondary ID
75387Method Name
High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Bupropion and Metabolite, SSpecimen Type
Serum RedSpecimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Frozen | 30 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
| Polymer gel separation tube (SST or PST) | Reject |
Reference Values
Reporting limit determined each analysis.
None Detected
Interpretation
Bupropion:
Maximum antidepressant response was observed at trough plasma concentrations of 50 to 100 ng/mL bupropion with virtually no response below 25 ng/mL.
Reported average bupropion peak plasma concentrations:
Adults:
Males:
Single 100 mg IR: 120 ± 10 ng/mL
Single 200 mg IR:220 ±20 ng/mL
Single 150 mg SR - 140 ±20 ng/mL
Females:
Single 100 mg IR: 150 ±10 ng/mL
Single 200 mg IR: 270 ±20 ng/mL
Single 150 mg SR: 140 ±20 ng/mL
Juveniles:
100 mg/day SR for 2 weeks: 25 ±8 ng/mL
200 mg/day SR for 2 weeks: 53 ±22 ng/mL
Hydroxybupropion:
Oral dose (mg); peak plasma concentrations (ng/mL)
Adults:
Single 100 IR: 296 ±154 ng/mL
Single 150 SR: 311 ±168 ng/mL
Single 300 ER: 402 ±145 ng/mL
Juveniles:
Daily 100 SR for 2 weeks: 451 ±214 ng/mL
Daily 200 SR for 2 weeks: 712 ±349 ng/mL
Half-life: approximately 15-22 hr
Day(s) Performed
Monday through Sunday
Report Available
6 to 10 daysPerforming Laboratory
NMS LabsCPT Code Information
80338
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FBUMT | Bupropion and Metabolite, S | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z3522 | Bupropion | 6706-6 |
| Z3523 | Hydroxybupropion | 9418-5 |
Test Classification
This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.Clinical Information
Refer to www.nmslabs.com/test-catalog.
Cautions
Specimens must be kept frozen. If specimens are not kept frozen, this may cause lower or negative values.