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Test Code FHLCA Immunoglobulin A (IgA) Heavy and Light Chain (HLC) Pairs, Kappa and Lambda with Ratio


Specimen Required


Collection Container/Tube: Red top or serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.75 mL serum

Collection Instructions:

1. Centrifuge immediately after coagulation (30 minutes) to prevent hemolysis.

2. Aliquot 0.75 mL of serum into a plastic vial.

3. Send refrigerate.


Secondary ID

75550

Reporting Name

IgA Heavy Light Chains (HLC), S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Hemolysis Reject
Lipemia Reject
Microbially-contaminated specimen Reject
Specimen containing particulate matter Reject

Clinical Information

Refer to www.labcorp.com/test-menu/

Reference Values

IgA Kappa (g/L): 0.48-2.82

IgA Lambda (g/L): 0.36-1.98

IgA Kappa:IgA Lambda ratio: 0.80-2.04

Interpretation

An elevated IgA heavy and light chain (HLC) pair ratio suggests a clonal proliferation of an IgA kappa clone of plasma cells.

 

A low IgA HLC pair ratio suggests a clonal proliferation of an IgA lambda clone of plasma cells.

Cautions

Decisions on patient evaluation and management must not be given on the basis of IgA kappa, IgA lambda, or IgA kappa:IgG lambda ratio measurements alone. Clinical history and other laboratory findings must be taken into account.

 

Heavy and light chain (HLC) quantitation should be used as a complementary method to serum protein electrophoresis.

 

The effect of therapeutic drugs on the measurement of IgA kappa and IgA lambda by this assay has not been evaluated.

 

Small increases in the concentrations of monoclonal IgA proteins may not result in an altered HLC pair ratio.

Day(s) Performed

Tuesday, Friday

Report Available

6 to 10 days

Performing Laboratory

LabCorp Burlington

CPT Code Information

83521 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FHLCA IgA Heavy Light Chains (HLC), S 74773-3

 

Result ID Test Result Name Result LOINC Value
Z5616 IgA Kappa, S 74864-0
Z5617 IgA Lambda, S 74865-7
Z5618 IgA K/L HLC Ratio 74869-9

Method Name

Turbidimetric