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Test Code FHLCG Immunoglobulin G (IgG) Heavy and Light Chain (HLC) Pairs, Kappa and Lambda with Ratio


Specimen Required


Collection Container/Tube: Red top or serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.75 mL serum

Collection Instructions:

1. Centrifuge immediately after coagulation (30 minutes) to prevent hemolysis.

2. Aliquot 0.75 mL of serum into a plastic vial.

3. Send refrigerate


Secondary ID

75551

Method Name

Turbidimetric

Reporting Name

IgG Heavy Light Chains (HLC), S

Specimen Type

Serum

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Hemolysis Reject
Lipemia Reject
Microbially-contaminated specimen Reject
Specimen containing particulate matter Reject

Clinical Information

Refer to www.labcorp.com/test-menu/

Reference Values

IgG Kappa: 4.03-9.78 g/L

IgG Lambda: 1.97-5.71 g/L

IgG Kappa:IgG Lambda ratio: 0.98-2.75

Interpretation

An elevated IgG heavy and light chain (HLC) pair ratio suggests a clonal proliferation of an IgG Kappa clone of plasma cells.

A low IgG HLC pair ratio suggests a clonal proliferation of an IgG Lambda clone of plasma cells.

Cautions

Decisions on patient evaluation and management must not be given on the basis of IgG Kappa, IgG Lambda, or IgG Kappa:IgG Lambda ratio measurements alone. Clinical history and other laboratory findings must be taken into account.

 

Heavy and light chain (HLC) quantitation should be used as a complementary method to serum protein electrophoresis.

 

The effect of therapeutic drugs on the measurement of IgG Kappa and IgG Lambda by this assay has not been evaluated.

 

Small increases in the concentrations of monoclonal IgG proteins may not result in an altered HLC pair ratio.

Day(s) Performed

Tuesday, Friday

Report Available

6 to 10 days

Performing Laboratory

LabCorp Burlington

CPT Code Information

83521 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FHLCG IgG Heavy Light Chains (HLC), S 74773-3

 

Result ID Test Result Name Result LOINC Value
Z5613 IgG Kappa, S 74862-4
Z5614 IgG Lambda, S 74863-2
Z5615 IgG K/L HLC Ratio 74868-1

Specimen Minimum Volume

Serum: 0.5 mL