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HelpTest Code FIN1A Interleukin 1-Alpha
Specimen Required
Patient preparation: Patient should NOT be on any corticosteroids, anti-inflammatory medications, or pain killers, if possible, for at least 48 hours prior to specimen collection.
Specimen Type: Serum
Collection Container/Tube:
Preferred: Red top
Acceptable: SST
Submission Container/Tube: Plastic vial
Specimen Volume: 3 mL
Collection Instructions:
1. Draw blood in a plain, red-top tube(s), serum-gel tube(s) is acceptable.
2. Centrifuge and aliquot 3 mL of serum into a plastic vial.
3. Send frozen.
Secondary ID
75908Method Name
Enzyme Immunoassay (EIA)
Reporting Name
Interleukin 1-AlphaSpecimen Type
SerumSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen | 30 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 1a is a 17,500 molecular weight peptide derived primarily from macrophages, fibroblasts, endothelial cells, and B cells. The major target cells are T and B cells, Fibroblasts, and Hepatocytes. Interleukin 1a shares a receptor with Interleukin 1b although they are significantly different structurally. Interleukin 1a promotes antigen specific immune responses, inflammation, Prostaglandin secretion, Colony Stimulating Factors, proteoglycanase, collagenase, and gelatinase activity, and release of Interleukin 2 from T cells. Levels are stimulated by liposaccharide, endotoxins, inflammatory agents, lectin, Tumor Necrosis Factor, and Interferons. Levels are suppressed by Corticosteroids, Prostaglandin E2, and suppressant lymphocytes.
Reference Values
Less than 3.9 pg/mL
Clinical Reference
1. JT Whicher and SW Evans. Cytokines in Disease. Clinical Chemistry 36: 1269-1281, 1990.
2. MP Bevilacqua, JS Pober, GR Majeau, W Fiers, RS Cotran, and MA Gimbrone. Recombinant Tumor Necrosis Factor Induced Pro-Coagulant Activity in Cultured Human Vascular Endothelium: Characterization and Comparison with Action of Interleukin-1. Proceedings of the National Academy of Science 83: 4533-4537, 1986.
Day(s) Performed
Monday through Friday
Report Available
12 to 14 daysPerforming Laboratory
Inter Science InstituteTest Classification
This test has not been cleared or approved by the US Food and Drug Administration. This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FIN1A | Interleukin 1-Alpha | 33821-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| FIN1A | Interleukin 1-Alpha | 33821-0 |