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Test Code FMSS2 Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A


Specimen Required


Specimen collection must occur between 14 weeks, 0 days and 24 weeks, 6 days gestation (based on the crown-rump length). Recommended time for maternal serum screening is 16 to 18 weeks gestation. Acceptable date ranges to collect the second samples are provided in the Integrated-1 report.

 

Collection Container/Tube: Serum gel or red top

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL Serum

Collection Instructions:

1. As soon as possible or within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.

2. Send refrigerate.

 

Note: This test requires that a previous first trimester specimen, FFMSS / Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT has been performed.


Secondary ID

75351

Method Name

Quantitative Chemiluminescent Immunoassay (CLIA)

Reporting Name

Maternal Serum Screen INT, Sp-2

Specimen Type

Serum

Specimen Minimum Volume

Serum: 1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  365 days
  Ambient  72 hours

Reject Due To

Hemolysis Reject
Plasma Reject

Clinical Information

Refer to https://ltd.aruplab.com/

Reference Values

An interpretive report will be provided.

Interpretation

An interpretive report will be provided. Part 2 must be completed in order to receive an interpretable result. If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided.

Cautions

A screen interpreted as "normal" misses approximately 15% of Down syndrome, 20% of open neural tube defects and 10% of trisomy 18 cases.

 

Abnormal results require follow-up with targeted ultrasound, genetic counseling, and consideration of fetal diagnostic testing.

Day(s) Performed

Monday through Sunday

Report Available

2 to 8 days

Performing Laboratory

ARUP Laboratories

CPT Code Information

81511

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FMSS2 Maternal Serum Screen INT, Sp-2 Not Provided

 

Result ID Test Result Name Result LOINC Value
Z5170 Patient's AFP 1834-1
Z5171 MoM for AFP 20450-3
Z5172 Patient's uE3 2250-9
Z5173 MoM for uE3 20466-9
Z5174 Patient's hCG, 2nd Trimester 19080-1
Z5175 hCG MoM, 2nd Trimester 20465-1
Z5176 Patient's DIA 23883-2
Z5177 MoM for DIA 35738-4
Z5178 PAPP-A Maternal 32046-5
Z5179 MoM for PAPP-A 32123-2
Z5180 Nuchal Translucency (NT) 12146-7
Z5181 MoM for NT 49035-9
Z5182 Nuchal Translucency (NT), Twin B 12146-7
Z5183 MoM for NT, Twin B 49035-9
Z5184 Maternal Screen Interpretation 49586-1
Z5185 Maternal Age At Delivery 21612-7
Z5186 Maternal Weight 29463-7
Z5187 Estimated Due Date 11778-8
Z5188 Gestational Age for Second Specimen 18185-9
Z5189 Dating 21299-3
Z5190 Number of Fetuses 11878-6
Z5191 Maternal Race 21484-1
Z5192 Insulin Req Maternal Diabetes 44877-9
Z5193 Smoking 64234-8
Z5194 Family Hx Neural Tube Defect 8670-2
Z5195 Family History of Aneuploidy 32435-0
Z5196 Specimen 19151-0
Z5197 Crown Rump Length 11957-8
Z5198 Crown Rump Length, Twin B 11957-8
Z5199 Sonographer Certification Number 49089-6
Z5200 Sonographer Name 49088-8
Z5201 Ultrasound Date 34970-4
Z5202 EER Maternal Serum, Integrated, Sp2 11526-1