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Test Code FSINS Sinemet, Serum


Specimen Required


***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***

Specimen Type: Serum

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood in a plain, red-top tube(s). Serum gel tube is not acceptable.

2. Centrifuge and send 1 mL of serum frozen in a preservative-free plastic vial. Specimen must be frozen immediately, or results will be compromised.


Secondary ID

75400

Method Name

High-Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Sinemet, Serum

Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Frozen 6 days

Reject Due To

Other Polymer gel separation tube (SST or PST)

Reference Values

Reporting limit determined each analysis.

 

Levodopa

 Units: mcg/mL 

 

Carbidopa

  Units: mcg/mL

Interpretation

Levodopa

The target plasma concentration of levodopa in Parkinsonian patients is 2 ± 0.5 mcg/mL. The average peak plasma levodopa concentration following a single oral dose of Sinemet containing 200 mg levodopa was 1.2 mcg/mL at 0.5 hours for normal release and 3.3 mcg/mL at 2 hours for controlled release. At steady-state, the average trough plasma levodopa concentration following oral Sinemet containing 200 mg levodopa was 0.07 mcg/mL for normal release and 0.16 mcg/mL for controlled release.

 

Carbidopa

Following a single oral dose of 250 mg levodopa and 25 mg carbidopa, peak plasma concentrations of carbidopa averaged 0.11 mcg/mL at 2.9 hours post dose. Carbidopa concentrations can decrease rapidly after collection unless flash frozen with dry ice.

Day(s) Performed

Monday - Sunday

Report Available

12 to 14 days

Performing Laboratory

NMS Labs

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FSINS Sinemet, Serum Not Provided

 

Result ID Test Result Name Result LOINC Value
Z3535 Levodopa 9385-6
Z3536 Carbidopa 9328-6

Test Classification

This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.