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HelpTest Code FSINS Sinemet, Serum
Specimen Required
***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL Serum
Collection Instructions:
1. Promptly centrifuge and aliquot serum into a plastic vial.
2. Immediately freeze specimen on dry ice or results will be compromised.
3. Send frozen.
Secondary ID
75400Method Name
High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Sinemet, SerumSpecimen Type
Serum RedSpecimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Frozen | 6 days |
Reject Due To
All specimens will be evaluated by the processing and performing laboratories for test suitability.Reference Values
Reporting limit determined each analysis.
Levodopa: None detected
Carbidopa: None detected
Interpretation
Levodopa
The target plasma concentration of levodopa in parkinsonian patients is 2 ± 0.5 mcg/mL. The average peak plasma levodopa concentration following a single oral dose of Sinemet containing 200 mg levodopa was 1.2 mcg/mL at 0.5 hours for normal release and 3.3 mcg/mL at 2 hours for controlled release. At steady state, the average trough plasma levodopa concentration following oral Sinemet containing 200 mg levodopa was 0.07 mcg/mL for normal release and 0.16 mcg/mL for controlled release.
Carbidopa
Following a single oral dose of 250 mg levodopa and 25 mg carbidopa, peak plasma concentrations of carbidopa averaged 0.11 mcg/mL at 2.9 hours post dose. Carbidopa concentrations can decrease rapidly after collection unless flash frozen with dry ice.
Day(s) Performed
Monday through Sunday
Report Available
7 to 14 daysPerforming Laboratory
NMS LabsCPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FSINS | Sinemet, Serum | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z3535 | Levodopa | 9385-6 |
| Z3536 | Carbidopa | 9328-6 |
Test Classification
This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.Clinical Information
Refer to www.nmslabs.com/test-catalog.