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Test Code LAB4115 HEPARIN -PF4 IgG ANTIBODY (HIT), Serum

Specimen Type

Preferred Specimen: Serum Tube (SST, Gold, Corvac, Tiger, Red Top Tube)
Alternative Specimen: Sodium Citrate Plasma (Blue Top Tube Filled to Maximum Fill line per Protocol)

Specimen Volume

1 mL

Minimum Volume

0.5 mL

Turnaround Time

24 Hours

Test Schedule

Monday - Friday

Sample Stability

Refrigerated: 2 days
Frozen: 2 years 

Method

Enzyme - Linked Immunosorbent Assay (ELISA)

Reference Ranges

<0.400 = Negative 

CPT Codes

86022

Interpretation

Detection of IgG antibodies directed against heparin/platelet factor 4 complexes that are implicated in the pathogenesis of immune-mediated type II heparin-induced thrombocytopenia (HIT-II).

 

Clinical picture of HIT type II:

-In patients not previously exposed to heparin

-Decrease in platelet count (thrombocytopenia) of 50% or more from baseline or postoperative peak

-Onset of thrombocytopenia beginning approximately 5 to 10 days after initiation of heparin this may or may not be associated with new or progressive thrombosis in patients treated with heparin

 

Patients previously exposed to heparin (especially within the preceding 100 days), in addition to the above findings, the onset of thrombocytopenia could occur within 24 to 48 hours after reexposure to heparin