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Test Code LAB4236 EPSTEIN-BARR VIRUS ANTIBODY PROFILE

Important Note

This test replaces MONO screen.

Serum must be frozen if not tested within 48 hours.

Specimen Type

Serum (SST, Gold, Corvac, Tiger, Red Top Tube)

Specimen Volume

1 mL

Minimum Volume

0.5 mL

Turnaround Time

Monday-Friday, Days

Sample Stability

Room Temp: 8 hours
Refrigerated: 2 days
Frozen: 1 year

Specimen Processing

Allow specimen to fully clot. Centrifuge specimen within 2 hours of collection. Pour off serum and freeze if testing is not performed within 48 hours.

Method

Qualitative Enzyme Immunoassay (EIA)

Reference Ranges

Negative

Synonyms

Epstein-Barr Virus, EBV

Test Components

EBNA (Anti-Epstein-Barr Virus Nuclear Antigen, IgG)

EBVG (Epstein-Barr Virus Viral Capsid Antigen IgG)

EBVM (Epstein-Barr Virus Viral Capsid Antigen IgM)

CPT Codes

86665,86664

Result Interpretation

Anti-Epstein-Barr Virus Nuclear Antigen (EBNA), IgG:

Index Value Interpretation

< 0.9

Negative for anti-EBNA IgG antibody

> 0.9 and 1.1

Equivocal

> 1.1

Positive for anti-EBNA IgG antibody

Index values which fall between 0.9 and 1.1 indicate an equivocal result. Subsequent samples should be drawn at least fourteen days later and tested simultaneously with the initial sample. If the subsequent sample is positive, seroconversion has occurred, which may be indicative of recent infection. If the subsequent sample remains equivocal, antibody status is undetermined and the sample is deemed equivocal. Other clinical and serological evidence should be sought in these cases.

Epstein-Barr Virus Viral Capsid Antigen IgG:

Index Value

Interpretation

< 0.9

Negative for anti-EB VCA IgG antibody

> 0.9 and < 1.1

Equivocal

> 1.1

Positive for anti-EB VCA IgG antibody

Index values which fall between 0.9 and 1.1 indicate an equivocal result. Subsequent samples should be drawn at least fourteen days later. If the subsequent sample is positive, seroconversion has occurred, which may be indicative of recent infection. If the subsequent sample remains equivocal, antibody status is undetermined and the sample is deemed equivocal. Other clinical and serological evidence should be sought in these cases.

 

Epstein-Barr Virus Viral Capsid Antigen IgM:

Index Value

Interpretation

< 0.9

Negative for anti-EB VCA IgM antibody

>0.9 and < 1.1

Equivocal

>1.1

Positive for anti-EB VCA IgM antibody

 

Index values which fall between 0.9 and 1.1 indicate an equivocal result. Subsequent samples should be drawn at least fourteen days later and tested simultaneously with the initial sample. If the subsequent sample is positive, seroconversion has occurred, which may be indicative of recent infection. If the subsequent sample remains equivocal, antibody status is undetermined and the sample is deemed equivocal. Other clinical and serological evidence should be sought in these cases.

 

Negative results do not rule out the diagnosis of disease associated with Epstein-Barr virus. The specimen may be drawn before appearance of detectable antibodies. Negative results in suspected early disease should be repeated in 3-4 weeks. This information should accompany the reporting of results to the clinician.

 

Specimen Rejection

Do not use lipemic, hemolyzed, or turbid specimens.