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Test Code LAB5977 Adulterants Survey, Chain of Custody, Random, Urine

Additional Codes

ADLTX

Useful For

Assess the possible adulteration of a urine specimen submitted for drug of abuse testing

 

Providing the urine creatinine concentration for normalization purposes

 

Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was always under the control of personnel involved with testing the specimen; this control implies that the opportunity for specimen tampering would be limited.

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes

Special Instructions

Reporting Name

Adulterants Survey, CoC, U

Specimen Type

Urine


Specimen Required


Supplies: Chain of Custody Kit (T282)

Container/Tube: Chain-of-custody kit containing the specimen containers, seals, and documentation required.

Specimen Volume: 1.5 mL

Collection Instructions: Collect a random specimen without preservative in the provided container, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.

Additional Information: Submitting less than 1.5 mL will compromise the ability to perform all necessary testing.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Clinical Information

Specimen adulteration is the manipulation of a sample that may cause false-negative test results for the presence of drugs of abuse. Common adulterants that may affect testing are water, soap, bleach, vinegar, oxidants, and salt. The adulteration testing includes assessment of creatinine concentration, pH, urine specific gravity, presence or absence of an oxidant, and presence or absence of nitrite.

 

Chain of custody is a record of the disposition of a specimen to document the individuals who collected the specimen, handled it, and performed the analysis. When a specimen is submitted in this manner, analysis will be performed in such a way that it will withstand regular court scrutiny.

Interpretation

For information see Adulterant Survey Algorithm.

Cautions

No significant cautionary statements

Clinical Reference

1. US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration (SAMHSA). Mandatory Guidelines for Federal Workplace Drug Testing Programs. Federal Register. 2017 January 23;82(13):FR 7920. Accessed July 15, 2024. Available at www.samhsa.gov/sites/default/files/workplace/frn_vol_82_7920_.pdf

2. US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration (SAMHSA). Drug-Free Workplace Programs: Employer Resources. Updated October 11, 2023. Accessed July 15, 2024. Available at www.samhsa.gov/workplace/resources

3. US Department of Health and Human Services (HHS), Substance Abuse and Mental Health Services Administration (SAMHSA). Mandatory Guidelines for Federal Workplace Drug Testing Programs. Updated October 12, 2023. Accessed July 15, 2024. Available at www.federalregister.gov/documents/2023/10/12/2023-21734/mandatory-guidelines-for-federal-workplace-drug-testing-programs

Method Description

All results are measured using spectrophotometry at wavelengths specified by the reagent manufacturer. The use of a refractometer may also be used in the specific gravity measurement.(Package inserts: Specimen Validity Test Creatinine. Roche Diagnostics; V3.0, 08/2015; Specimen Validity Test Nitrite. Roche Diagnostics; V3.0, 08/2018, Specimen Validity Test Oxidant. Roche Diagnostics; V 3.0, 08/2018; Specimen Validity Test pH Roche Diagnostics; V3.0, 02/2019, Specimen Validity Test Specific Gravity. Roche Diagnostics; V4.0, 08/2022)

Day(s) Performed

Monday through Saturday

Report Available

2 to 3 days

Specimen Retention Time

2 weeks

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ADLTX Adulterants Survey, CoC, U 58715-4

 

Result ID Test Result Name Result LOINC Value
36121 Creatinine, U 2161-8
36122 Specific Gravity 5810-7
36123 pH 2756-5
36124 Oxidants 58714-7
36125 Nitrites 32710-6
36126 Comment 48767-8

Method Name

Spectrophotometry

Reference Values

Cutoff concentrations

Oxidants: 200 mg/L

Nitrites: 500 mg/L

Testing Algorithm

For more information see Adulterant Survey Algorithm.

Forms

1. Chain of Custody Request is included in the Chain-of-Custody Kit (T282).

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.